ABSTRACT
Kola bark extract have been widely used in tradition medicine for thousand of year, it improves liver functions and provides protection against high fat fed metabolic rats. Present investigations were carried out on the hepatoprotective role of Kola bark extract meal treatment to high fat fed wistar rat. Healthy adult male wistar rats were divided into four groups Group I: rats were fed a standard Laboratory diet (groups match) (20g/rat/day), Group II: rats were fed a high-fat diet alone (3.6g/rat/day), Group III: rats were fed with combined mixture of 70% of high-fat diet with 30% Kola bark meal (9.8g/rat /day), Group/ V: rats were fed with high fat diet and was administered with Lipitor (Atovastatin) (10mg/rat/day) . The rats were sacrificed at the end of the experiment (two weeks) period. The high fat fed rat substantially elevated its serum and liver tissue AST, ALT, ALP, bilirubin with decreased in total protein levels. Where as the levels of all parameters significantly restored towards normalization by the kola bark husk meal treatment. The results obtained suggest that the Kola bark meal have potent hepatoprotective action on high fat fed rats. A companion of the performance in both Kola bark meal and Lipitor treatment on high fat fed rat in respect of hepatoprotective role is clearly indicator that the Kola bark meal treatment was more and related to the result of Lipitor as well as to the normal level.
CHAPTER ONE
1.0 INTRODUCTION
BACKGROUND OF THE STUDY
Liver is the largest and most complex internal organ in the body. It plays an important role in the maintenance of internal environment through its multiple and diverse functions. Liver is involved in several vital functions such as metabolism, secretion and storage. Hepatitis or inflammatory disorder involves inflammation and damage to the hepatocytes. Hepatitis is one of the most prevalent diseases in the world. Every year 18,000 people had been reported to die due to liver cirrhosis caused by viral hepatitis [L] Ectopic fat storage occurs in obesity particularly in the liver leading to a condition termed nonalcoholic fatty liver disease [NAFLD] characterized by varying degree of liver injury that progresses from steatosis to tratohepatitis, fibrosis and necrosis Due to its prominent association with IR (insulin resistance). Obesity, NAFLD is regarded as the hepatic manifestation of metabolite [3] syndrome. Liver has great capacity to detoxicate toxic substances.
Kola pod is the traditional health food around the world. Kola pod Husk meal is the residue after grinding the pod of kola and filtration, and it is an excellent source in slightly high in fiber (16.74%), low in crude protein (9.98%), moderate NFE (42.391) and metabolizable energy 2497 kcal/kg, and......
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